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Package Inserts:

Hemopure Package Insert (SA)
Oxyglobin Package Insert (US)
Oxyglobin Package Insert (EU)

Hemopure Interference Literature

General Laboratory

Callas DD, Clark TL, Moreira PL, Lansden C, Gawryl MS, Kahn S, Bermes EW. In vitro effects of a novel hemoglobin-based oxygen carrier on routine chemistry, therapeutic drug, coagulation, hematology, and blood bank assays. Clin Chem. 1997;43(9):1744-1748.

Wolthuis A, Peek D, Scholten R, Moreira P, Gawryl MS, Clark T, Westerhuis L. Effect of the hemoglobin-based oxygen carrier HBOC-201 on laboratory instrumentation: Cobas Integra, Chiron Blood Gas Analyzer 840, Sysmex SE-9000 and BCT. Clin Chem Lab Med. 1999;37(1):71-76.

Chemistry

Jahr JS, Osgood S, Rothenberg SJ, Qiao-Ling L, Butch AW, Gunther R, Cheung A, Driessen B. Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure and Hemolink). Anesth Analg. 2005;100(2):431-436.

Ma Z, Monk TG, Goodnough LT, McClellan A, Gawryl M, Clark T, Moriera P, Keipert PE, Scott MG. Effect of hemoglobin- and perflubron-based oxygen carriers on common clinical laboratory tests. Clin Chem. 1997;43(9):1732-1737.

Moreira PL, Lansden CC, Clark TL, Gawryl MS. Effect of Hemopure on the performance of Ektachem and Hitachi clinical analyzers. Clin Chem. 1997;43(9):1790-1791.

Rea, D.M., Posey, A., Caffo, A.L. Interference Testing of HBOC-201, an Oxygen Based Therapeutic, with Dade Behring Chemistry Assays Performed on the Dimension® Clinical Chemistry System. Accepted for oral presentation at the American Association for Clinical Chemistry 2005 Annual Meeting, Orlando, FL, July24-28, 2005, abstract.

Coagulation

Moreira PL, Lansden CC, Clark TL, Gawryl MS. Effect of Hemopure on prothrombin time and activated partial thromboplastin time on seven coagulation analyzers. Clin Chem. 1997;43(9):1792.

Sarkozi L, Jacobs E, Clark T, Gawryl MS, Simson E. Effect of hemoglobin-based oxygen carrier-201 on common chemistry laboratory procedure. Clin Chem. 1997;43(9):1792-1794.

Plasma Hemoglobin Measurements

Jahr JS, Lurie F, Driessen B, Davis JA, Gosselin R, Gunther RA. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8.

Kunicka J, Malin M, Zelmanovic D, Katzenberg M, Canfield W, Shapiro P, Mohandas N. Automated quantitation of hemoglobin-based blood substitutes in whole blood samples. Am J Clin Pathol. 2001 Dec;116(6):913-9.

Lurie F, Jahr JS, Driessen B. The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobin-Raffimer (Hemolink). Anesth Analg. 2002 Oct;95(4):870-3, table of contents.

Moon-Massat PF, Tierney JP, Hock KG, Scott MG. Hitachi Hemolytic Index correlates with HBOC-201 concentrations: Impact on suppression of analyte results. Clin Biochem. 2007 Dec 23; [Epub ahead of print].

Oxyglobin Interference Literature

Blood Gas

Jahr JS, Lurie F, Driessen B, Tang Z, Louie RF, Kullar R, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin based oxygen carrier (HBOC) infusion. Clin Lab Sci. 2000;13(3):173-178.

Estrada RR. Are i-STAT results adversely affected by an artificial blood substitute in vivo? Mil Med. 2006 May;171(5):381-8.

Chemistry

Jahr JS, Osgood S, Rothenberg SJ, Qiao-Ling L, Butch AW, Gunther R, Cheung A, Driessen B. Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure and Hemolink). Anesth Analg. 2005;100(2):431-436.

Osgood SL, Jahr JS, Desai P, Tsukamoto J, Driessen B. Does methemoglobin from oxidized hemoglobin-based oxygen carrier (hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT Biochemistry Analyzer)? Anesth Analg. 2005 Feb;100(2):437-9.

Hematology

Callan MB, Giger U, Oakley DA, Scotti MV, Shofer FS. Evaluation of an automated system for hemoglobin measurement in animals. Am J Vet Res. 1992;53(10):1760-1764.

March H, Barger A, McCullough S, Shaeffer D, MacWilliams P. Use of the ADVIA 120 for differentiating intracellular and intracellular hemoglobin tests. Veterinary Clinical Pathology 2005;34(2)106-109

Plasma Hemoglobin Measurements

Jahr JS, Lurie F, Driessen B, Davis JA, Gosselin R, Gunther RA. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8.

Kunicka J, Malin M, Zelmanovic D, Katzenberg M, Canfield W, Shapiro P, Mohandas N. Automated quantitation of hemoglobin-based blood substitutes in whole blood samples. Am J Clin Pathol. 2001 Dec;116(6):913-9.

Lurie F, Jahr JS, Driessen B. The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobin-Raffimer (Hemolink). Anesth Analg. 2002 Oct;95(4):870-3.